Abstract
A new series of quinolinyl- and phenantridinyl-acetamides were synthesizer and evaluated against bradykinin B1 receptor. In vitro metabolic stability data were reported for the key compounds.The analgesic effect of compound 20 from the phenantridine series was proved in-vivo.
Copyright © 2012 Elsevier Ltd. All rights reserved.
MeSH terms
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Acetamides / chemical synthesis*
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Acetamides / pharmacology
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Analgesics / chemical synthesis
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Analgesics / pharmacology
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Bradykinin B1 Receptor Antagonists*
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Cell Line
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Humans
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Metabolism
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Phenanthrenes / chemical synthesis*
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Phenanthrenes / pharmacology
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Quinolines / chemical synthesis*
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Quinolines / pharmacology
Substances
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Acetamides
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Analgesics
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Bradykinin B1 Receptor Antagonists
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Phenanthrenes
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Quinolines